-Adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells
نویسندگان
چکیده
Einsley Janowski, Regina Day, Alexander Kraev, John C. Roder, Lars Cleemann, and Martin Morad Medical University of South Carolina, Charleston, South Carolina; Georgetown University, Washington, DC; Uniformed Services University of the Health Sciences, Bethesda, Maryland; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; and Mount Desert Island Biological Laboratory, Salsbury Cove, Maine
منابع مشابه
beta-adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells.
The function, regulation, and molecular structure of the cardiac Na(+)/Ca(2+) exchangers (NCXs) vary significantly among vertebrates. We previously reported that beta-adrenergic suppression of amphibian cardiac NCX1.1 is associated with specific molecular motifs. Here we investigated the bimodal, cAMP-dependent regulation of spiny dogfish shark (Squalus acanthias) cardiac NCX, exploring the eff...
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BACKGROUND The Na-Ca exchanger (NCX) is a critical calcium efflux pathway in excitable cells, but little is known regarding its autonomic regulation. METHODS AND RESULTS We investigated beta-adrenergic receptor and muscarinic receptor regulation of the cardiac NCX in control and heart failure (HF) conditions in atrially paced pigs. NCX current in myocytes from control swine hearts was signifi...
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The Na(+)-Ca(2+) exchanger (NCX) is a major Ca(2+)-regulating protein encoded by three genes: NCX1, NCX2, and NCX3. They share a sequence homology of approximately 65%. NCX1 protein is expressed ubiquitously, and NCX2 and NCX3 are expressed almost exclusively in the brain. We have shown previously (Kimchi-Sarfaty et al., 2002) that treatment of NCX1-transfected human embryonic kidney (HEK) 293 ...
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q 2q Ž . 2q Objective: The cardiac sarcolemmal Na rCa -exchanger NCX plays an important role in the maintenance of the myocardial Ca homeostasis which is altered in cardiac hypertrophy and failure. The aim of the present study was to investigate whether a-adrenergic stimulation known to induce cardiac hypertrophy might be involved in the regulation of the sarcolemmal NCX. Methods: Adult rat Ž ....
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NA /CA2 EXCHANGER (NCX) proteins constitute a family of solute carriers that provide the major pathway for removal of calcium from the cytosol in exchange for three times as many sodium ions. The vertebrate NCX proteins are expressed as tissue-specific subtypes coded by multiple genes (NCX1, NCX2, and NCX3 in mammals) and further diversified by variable splicing (e.g., NCX1.1, NCX1.2, and NCX1....
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